Baena-Lopez laboratory
CASPASELAB: "Research fuels progress" 

2024

Cellular stress management by caspases.

Baena-Lopez LA, Wang L, Wendler F.
Curr Opin Cell Biol. 2024 Feb;86:102314. doi: 10.1016/j.ceb.2023.102314. PMID: 38215516

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2023

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Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
Luscombe VB, Baena-López LA, Bataille CJR, Russell AJ, Greaves DR.
Eur J Pharmacol. 2023 Oct 5;956:175960. doi: 10.1016/j.ejphar.2023.175960. Epub 2023 Aug 3.
PMID: 37543157

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Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network.

Ella S Kim et al. G3 (Bethesda). 2023 Aug 30;13(9):jkad124. doi: 10.1093/g3journal/jkad124.
PMID: 37279923 

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Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells.

Galasso A, Xu DC, Hill C, Iakovleva D, Stefana MI, Baena-Lopez LA.
EMBO Rep. 2023 Apr 11:e51716. doi: 10.15252/embr.202051716. PMID: 37039000

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This paper was published with a supporting news and views article: "Something new under the sun: caspases promote cell survival under moderate heat stress"

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Regulation and coordination of the different DNA damage responses and their role in tissue homeostasis maintenance. Baena-López LA, Baonza A, Estella C, Herranz H. Front Cell Dev Biol. 2023 Mar 13;11:1175155. doi: 10.3389/fcell.2023.1175155. eCollection 2023. PMID: 36994105 

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2022

Non-apoptotic activation of Drosophila Caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors.

Derek Cui Xu, Kenneth M. Yamada, Luis Alberto Baena-Lopez. Cell Rep. 2022 Apr 19;39(3):110718. doi: 10.1016/j.celrep.2022.110718.PMID: 35443185.

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Caspases help to spread the message via extracellular vesicles.
Hill C, Dellar ER, Baena-Lopez LA. FEBS J. 2022 Mar 5. doi: 10.1111/febs.16418. Online ahead of print.
PMID: 35246932 Review.

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A LexAop>UAS>QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes.

Franz Wendler, Sangbin Park, Claire Hill, Alessia Galasso, Kathleen R. Chang, Iman Awan, Yulia Sudarikova, Mar Bustamante, Sichen Liu, Ethan Sung, Gabrielle Aisabonoko, Seung K. Kim, Luis Alberto Baena-Lopez.

Scientific Reports. 2022 Mar 9;12(1):3835. doi: 10.1038/s41598-022-07852-7.

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Confocal microscopy analysis reveals that only a small proportion of extracellular vesicles are successfully labelled with commonly utilised staining methods.
Melling GE, Conlon R, Pantazi P, Dellar ER, Samuel P, Baena-Lopez LA, Simpson JC, Carter DRF.
Scientific Reports. 2022 Jan 7;12(1):262. doi: 10.1038/s41598-021-04225-4. PMID: 34997141 Free PMC article.

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Transgenic Drosophila lines for LexA-dependent gene and growth regulation.
Chang KR, Tsao DD, Bennett C, Wang E, Floyd JF, Tay ASY, Greenwald E, Kim ES, Griffin C, Morse E, Chisholm T, Rankin AE, Baena-Lopez LA, Lantz N, Fox E, Kockel L, Kim SK, Park S. G3 (Bethesda). 2022 Mar 4;12(3):jkac018. doi: 10.1093/g3journal/jkac018.
PMID: 35100369 Free PMC article.

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2020

Non-Lethal Message from the Holy Land: The first International Conference on Non-Apoptotic Roles of Apoptotic Proteins.

Eli Arama, L. Alberto Baena-Lopez, Howard Fernhead. The FEBS journal, in press.

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Regulated cell death mechanisms and their crosstalk with the immune system. Baena-Lopez, L.A. (2020, July 30).  In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 10, 2020, from https://hstalks.com/bs/4357/

 

2019

Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence.
Arthurton L, Nahotko DA, Alonso J, Wendler F, Baena-Lopez LA. EMBO Reports. 2020 Dec 3;21(12):e48892. doi: 10.15252/embr.201948892. Epub 2020 Nov 1. PMID: 33135280 Free PMC article.

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Lessons in genome engineering: opportunities, tools and pitfalls

Ingrid Poernbacher, Sam Crossman, Joachim Kurth, Hisashi Nojima, Alberto Baena-Lopez, Cyrille Alexandre, Jean-Paul Vincent

bioRxiv 710871; doi: https://doi.org/10.1101/710871

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2018

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Baena-Lopez LA,  Arthurton L, Bischoff M, Vincent JP, Alexandre C, McGregor R. Development. 2018 December 2018 145: dev170811 doi: 10.1242/dev.170811

Learning on the fly: The interplay between Caspases and Cancer

Xu DC, Arthurton L, Baena-Lopez LA. Biomed. Research International. 2018 March 14. [Epub ahead of print] 

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All about the caspase-dependent functions without cell death.

Baena-Lopez LA. Semin Cell Dev Biol. 2018 Jan 20. [Epub ahead of print] 

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2017

Non-apoptotic Caspase regulation of stem cell properties.

Baena-Lopez LA, Arthurton L, Xu DC, Galasso A.

Semin Cell Dev Biol. 2017 Nov 1. [Epub ahead of print]

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2014

 

Patterning and growth control by membrane-tethered Wingless.

Alexandre C, Baena-Lopez A, Vincent JP.

Nature. 2014 Jan 9;505(7482):180-5. doi: 10.1038/nature12879. Epub 2013 Dec 25.

 

2013

 

Accelerated homologous recombination and subsequent genome modification in Drosophila.

Baena-Lopez LA, Alexandre C, Mitchell A, Pasakarnis L, Vincent JP.

Development. 2013 Dec;140(23):4818-25. doi: 10.1242/dev.100933. Epub 2013 Oct 23.

 

Mechanisms and mechanics of cell competition in epithelia.

Vincent JP, Fletcher AG, Baena-Lopez LA.

Nat Rev Mol Cell Biol. 2013 Sep;14(9):581-91. doi: 10.1038/nrm3639. Epub 2013 Aug 14. Review.

 

2012

 

Integration of morphogen signalling within the growth regulatory network.

Baena-Lopez LA, Nojima H, Vincent JP.

Curr Opin Cell Biol. 2012 Apr;24(2):166-72. doi: 10.1016/j.ceb.2011.12.010. Epub 2012 Jan 16. Review.

 

2010

 

dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.

Ziosi M, Baena-López LA, Grifoni D, Froldi F, Pession A, Garoia F, Trotta V, Bellosta P, Cavicchi S, Pession A.

PLoS Genet. 2010 Sep 23;6(9):e1001140. doi: 10.1371/journal.pgen.1001140.

 

2009

 

Wingless promotes proliferative growth in a gradient-independent manner.

Baena-Lopez LA, Franch-Marro X, Vincent JP.

Sci Signal. 2009 Oct 6;2(91):ra60. doi: 10.1126/scisignal.2000360.

 

Characterization of the interface between normal and transformed epithelial cells.

Hogan C, Dupré-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-López LA, Vincent JP, Itoh Y, Hosoya H, Pichaud F, Fujita Y.

Nat Cell Biol. 2009 Apr;11(4):460-7. doi: 10.1038/ncb1853. Epub 2009 Mar 15.

 

2008

 

Upregulation of glypicans in Hippo mutants alters the coordinated activity of morphogens.

Rodríguez I, Baena-Lopez LA, Baonza A.

Fly (Austin). 2008 Nov-Dec;2(6):320-2. Epub 2008 Nov 21.

 

The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.

Baena-Lopez LA, Rodríguez I, Baonza A.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9645-50. doi: 10.1073/pnas.0803747105. Epub 2008 Jul 9.

 

The expression of heat shock protein HSP60A reveals a dynamic mitochondrial pattern in Drosophila melanogaster embryos.

Baena-López LA, Alonso J, Rodriguez J, Santarén JF.

J Proteome Res. 2008 Jul;7(7):2780-8. doi: 10.1021/pr800006x. Epub 2008 Jun 13.

 

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.

Franch-Marro X, Wendler F, Guidato S, Griffith J, Baena-Lopez A, Itasaki N, Maurice MM, Vincent JP.

Nat Cell Biol. 2008 Feb;10(2):170-7. doi: 10.1038/ncb1678. Epub 2008 Jan 13.

 

2006

 

Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster.

Baena-Lopez LA, García-Bellido A.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13734-9. Epub 2006 Sep 1.

 

2005

 

Characterization of the Drosophila melanogaster mitochondrial proteome.

Alonso J, Rodriguez JM, Baena-López LA, Santarén JF.

J Proteome Res. 2005 Sep-Oct;4(5):1636-45.

 

The orientation of cell divisions determines the shape of Drosophila organs.

Baena-López LA, Baonza A, García-Bellido A.

Curr Biol. 2005 Sep 20;15(18):1640-4.

 

Constitutive expression of heat shock protein p23 correlates with proneural territories in imaginal discs of Drosophila melanogaster.

Alonso J, Rodriguez JM, Baena-López LA, Alonso MT, Santarén JF.

Proteomics. 2005 Sep;5(14):3604-13.

 

2003

 

Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs.

Baena-López LA, Pastor-Pareja JC, Resino J.

Development. 2003 Dec;130(26):6497-506.

 

Genetic requirements of vestigial in the regulation of Drosophila wing development.

Baena-López LA, García-Bellido A.

Development. 2003 Jan;130(1):197-208.